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KMID : 0605919950010010001
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Journal of Korean Association of Pediatric Surgeons
1995 Volume.1 No. 1 p.1 ~ p.7
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Evolutionary Patterns with Age of Acetylcholinesterase Activity of Rectal Suction Biopsies in Hirschsprung
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Park Woo-Hyun
Choi Soon-Ok
Kim Sang-Pyo
Chang Eun-Sook
Paik Tae-Won
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Abstract
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The acetylcholinesterase(ACHE) activity in 37 biopsies from the patients with Hirschsprung’s disease was analysed for histochemical patterns according to age, and its evolutional behavior was also assessed. The histochemical criterion used for the diagnosis of Hirschsprung’s disease was that of Chow, i.e., ’the presence of many coarse discrete cholinergic fibers in the muscularis mucosae and in the immediately subjacent submucosa regardless of an infiltration of cholinergic fibers in the lamina propria.’ The acetylcholinesterase activity in Hirschsprung’s disease was further classified into 3 patterns, advocated by de Brito and Maksoud : Pattern Ⅰ-many thick fibers exclusively in the muscularis mucosae and submucosa(newborn pattern). Pattern Ⅱ-many thin fibers in the muscularly mucosae and submucosa with a clear infiltration of cholinergic fibers in the lamina propria(classical pattern). Pattern Ⅲ-an intermediate pattern showing morphological characteristics of the two patterns with predominance of one or the other. Of 37 biopsies, Pattern 1 was seen exclusively in 16 biopsies taken from the neonates. Pattern Ⅲ was Ⅱ of 37 biopsies and it was mainly seen in children between 2 to 12 months of age. Pattern Ⅱ was seen in all 3 biopsies of older than 1 year of age and in 6 ones of 3 to 12 months of age. In summary, this study reinforces the impression that there is an evolutional character of the distribution and morphology of the cholinergic ACHE positive fiber with age. In other words, ACHE activity in Hirschsprung’s disease appears to evolve with age from the newborn pattern to the intermediate pattern finally to the classical pattern.
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KEYWORD
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Acetylcholinesterase, Rectal suction biopsy, Hirschsprung’s disease
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